Renal tubular acidosis, arthritis and autoantibodies: primary Sjögren's syndrome in childhood

Renal tubular acidosis in childhood

Increased knowledge on the genetics, the pathophysiology, the natural history and the treatment of renal tubular acidosis (RTA) has begun to clarify this often confusing field. To help pediatricians better acquainted with the physiological and genetic basis of the various types of RTA, to facilitate early diagnosis and treatment with the ultimate aim of preventing the significant growth failure...

Prevalence of distal renal tubular acidosis in primary Sjögren's syndrome.

OBJECTIVES Our objectives were to analyse the prevalence of distal renal tubular acidosis (dRTA) in primary SS (pSS) and to compare a novel urinary acidification test with furosemide and fludrocortisone (FF) with the gold standard ammonium chloride (NH4Cl) to detect dRTA. METHODS Urinary acidification was assessed in 57 pSS patients using NH4Cl and FF. A urinary acidification defect was defin...

Renal Tubular Acidosis in Patients with Primary Sjögren's Syndrome

Primary Sjögren's syndrome (pSS) is characterized by lymphocytic infiltration of the exocrine glands resulting in decreased saliva and tear production. It uncommonly involves the kidneys in various forms, including tubulointerstitial nephritis, renal tubular acidosis, Fanconi syndrome, and rarely glomerulonephritis. Its clinical symptoms include muscle weakness, periodic paralysis, and bone pai...

(pink Disease and Primary Renal Tubular Acidosis.)

Renal tubular acidosis.

Renal tubular acidosis is a relatively uncommon clinical syndrome characterized by the inability of the kidney to adequately excrete hydrogen ions, retain adequate bicarbonate, or both. This syndrome can be categorized into 3 separate disorders, each with unique clinical characteristics. Although an uncommon finding, prompt and inexpensive tests can lead to early intervention and subsequently r...